성견 1면 골결손부에서 Bioactive Glass가 치주조직 치유에 미치는 영향
The effects of bioactive glass on the periodontal healing of 1-wall intrabony defects in dogs
소속 상세정보
박원영/Weon-Yeong Park
조규성/채중규/김종관/최성호/Kyoo-Sung Cho/Jung-Kiu Chai/Chong-Kwan Kim/Seong-Ho Choi
KMID : 0363019980280010145
Abstract
결 론
본 연구는 성견에서 1면 치조골 결손이 있는 경우, bioactive glass를 이식했을 때 접합상
피, 치조골, 백악질, 결합조직 등 치주조직 재생과 치유에 미치는 영향을 평가하기 위해 실
시하였다. 성견의 소구치 근심면에 4㎜ 깊이, 4㎜ 넓이의 1면 골결손부를 실험적으로 형성한
후 치주수술만을 시행한 군을 대조군으로, bioactive glass를 이식한 군을 실험군으로 설정
하여 실험하고, 술후 8주에 치유결과를 조직학적으로 비교 관찰하여 다음과 같은 결과를 얻
었다.
1. 치은변연 위치는 대조군에서 -1.30±0.73㎜, 실험군에서 -1.40±0.78㎜로 나타났으며, 대
조군과 실험군간에 유의성 있는 차이는 없었다.
2. 백악법랑경계부-접합상피 하단(접합상피의 근단이동 정도)은 대조군에서 1.74±0.47㎜,
실험군에서 1.12±0.36㎜로 나타났으며, 대조군과 실험군간에 유의성 있는 차이가 있었다
(P<0.01).
3. 백악질 형성량은 대조군에서 2.06±0.73㎜, 실험군에서 2.62±0.37㎜로 나타났으며, 대조
군과 실험군간에 유의성 있는 차이는 없었다.
4. 신생골 형성량은 대조군에서 1.83±0.74㎜, 실험군에서 2.39±0.59㎜로 나타났으며, 대조
군과 실험군간에 유의성 있는 차이는 없었다.
이상의 결과에서 볼 때, 성견의 1면 골결손부에서 bioactive glass를 사용할 때 접합상피
의 근단 이동이 적었으나, 신생골과 신생백악질 형성에는 유의성 있는 개선이 없었다.
The ultimate goal of periodontal therapy is the regeneration of periodontal tissue
which has been lost due to destructive periodontal disease, and numerous kinds of
materials and techniques have been developed to achieve this goal. Bone grafts include
autografts, allografts, xenografts and synthetic grafts. Among the synthetic grafts,
bioactive glass has been used in dentistry for more than ten years and Fetner reported
improved new bone formation and more amount of new attachment after grafting
PerioGlas, a kind of bioactive glass, in 2-wall defects of monkeys in 1994. It Is well
known that 1-wall defects have less osteogenic potential and more epithelial migration,
so we need to study the erect of bioactive glass in 1-wall dejects in dogs.
The present study evaluates the effect of bioactive glass on the epithelial migration,
alveolar bone regeneration, cementum formation and gingival connective tissue
attachment in intrabony detects of dogs. Four millimeter deep and four millimeter wide
1-wall defects were surgically cheated in the mesial aspects of premolars. The test
group received bioactive glass with a flap procedure and the control underwent flap
procedure only. Histologic analysis after 8 weeks of healing revealed the following
results :
1. The height of gingival margin was 1.30±0.73㎜ above CEJ in the control and 1.40
±0.78㎜ in the test group. There was no statistically significant difference between the
two group.
2. The length of epithelial growth (the distance from CEJ to the apical end of JE)
was 1.74±0.47㎜ in the control and 1.12±0.36㎜ in the test group. These was a
statistically significant difference between the two groups (P<0.01)
3. The length of new cementum was 2.06±0.73㎜ in the control and 2.62±0.37㎜ in
the test group. There was no statistically significant difference between the two groups.
4. The length of new bone was 1.83±0.74mm in the control and 2.39±0.59mm in the
test group. There was no statistically significant difference between the two groups.
These results suggest that the use of bioactive glass 1-wall intrabony defects has
significant effect on the prevention of junctional epithelium migration, but doesn't haute
any significant effect on new bone and new cementum formation.
키워드
periodontal regeneration; bone graft; bioactive glass; 1-wall intrabony defect;
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